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Further complicating this pathway, it has been demonstrated that a metabolite of cysteine, hydrogen sulfide (H2S), can regulate CRH release effectively (Kimura 2002)

Glutathione (GSH) is a highly specialized, endogenous tripeptide natively synthesized in nearly every cell of the human body

Thus, lipotoxicity creates a vicious cycle in which the metabolic derangement caused by insulin deficiency directly promotes beta cell apoptotic pathways and further decreases metabolism [102, 103]

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